RNA-Based Therapeutics in Cardiovascular Disease

RNA-based therapies—including antisense oligonucleotides, small interfering RNAs (siRNAs), and messenger RNA (mRNA) platforms—are revolutionizing medicine by enabling precise modulation of gene expression. In cardiology, these approaches offer opportunities to silence harmful proteins (such as PCSK9) or restore beneficial ones. Recent approvals of siRNA-based lipid-lowering drugs have validated this therapeutic class, while preclinical studies are exploring applications in arrhythmias, myocardial regeneration, and fibrosis reduction.

The flexibility of RNA therapeutics allows rapid adaptation to new targets, but challenges remain in delivery, durability, and off-target effects. Nanoparticle-based carriers and tissue-specific delivery systems are being refined to optimize cardiac uptake. This track will highlight breakthroughs in RNA-based therapies, discuss lessons learned from other fields such as oncology, and explore their future role in cardiovascular medicine. Attendees will gain perspective on how genetic precision could complement conventional pharmacology in managing heart failure and ischemic disease.

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