Novel Lipid-Lowering Therapies and Cardiovascular Outcomes
Dyslipidemia is a well-established risk factor for atherosclerotic cardiovascular disease, and while statins remain the cornerstone of therapy, residual risk persists for many patients. The advent of novel lipid-lowering agents—including PCSK9 inhibitors, bempedoic acid, and ANGPTL3 inhibitors—offers potent LDL reduction beyond statin therapy. Additionally, therapies targeting triglyceride-rich lipoproteins and lipoprotein(a) are under active development, aiming to address previously untreatable risk factors.
Recent outcome trials have demonstrated substantial event reduction with these agents, particularly in high-risk populations. Beyond LDL lowering, attention is turning toward pleiotropic effects such as plaque stabilization and inflammation reduction. This track will explore the expanding therapeutic landscape, discuss barriers to access and cost-effectiveness, and examine integration into treatment guidelines. Participants will also gain insights into ongoing clinical trials that could redefine lipid management strategies in the coming decade.
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