Circulating microRNAs and Novel Biomarkers in Diagnosis
Circulating microRNAs (miRNAs) have emerged as powerful biomarkers in cardiovascular disease, reflecting gene regulatory changes involved in myocardial stress, remodeling, and apoptosis. Unlike conventional biomarkers such as BNP or troponins, miRNAs offer insights into molecular pathways driving disease progression. Studies have identified specific miRNA signatures associated with heart failure, angina, and myocardial infarction, suggesting their potential role in early diagnosis and prognosis. Moreover, their stability in plasma and non-invasive detectability make them attractive candidates for routine clinical use.
Beyond miRNAs, novel biomarkers including galectin-3, ST2, and growth differentiation factor-15 are reshaping diagnostic and risk stratification frameworks. These markers not only predict adverse outcomes but also serve as therapeutic targets in clinical trials. This track will delve into the clinical translation of miRNAs and emerging biomarkers, discussing assay standardization, regulatory challenges, and integration with existing diagnostic platforms. Attendees will gain an understanding of how biomarker-driven precision medicine could redefine cardiovascular care.
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